Here's a site I stumbled upon a few weeks ago and it's become one of my favorite online comics (I admit that's a very small group). The premise is simple, in the words of creator Dan Walsh:
"Garfield Minus Garfield is a site dedicated to removing Garfield from the Garfield comic strips in order to reveal the existential angst of a certain young Mr. Jon Arbuckle. It is a journey deep into the mind of an isolated young everyman as he fights a losing battle against loneliness and depression in a quiet American suburb."
And it works! The result is zany, beat, surreal, and, at least for me, provokes a lot more chuckles than the big orange cat does on a daily basis.
Walsh says Garfield's creator, Jim Davis, has also seen the strip and approves, graciously calling the work “an inspired thing to do” and thanking "Walsh for enabling him to see another side of 'Garfield.'"
Another web artist was inspired by this to create "Calvin minus Hobbes", where the toy stuffed tiger remains just that and we never see the full-sized companion of Calvin's imagination. But he gave the strip up, saying the result was just too sad.